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Sampling of Pertinent Scientific Literature Related to OralFitness INDEX

Meta-analysis and Systematic Reviews

  1. Al-Majid A, Alassiri S, Rathnayake N, Tervahartiala T, Gieselmann DR, Sorsa T. Matrix Metalloproteinase-8 as an Inflammatory and Prevention Biomarker in Periodontal and Peri-Implant Diseases. Int J Dent. 2018 Sep 16;2018:7891323. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165625/ (Free PMC Article)†
  2. de Morais EF, Pinheiro JC, Leite RB, Santos PPA, Barboza CAG, Freitas RA. Matrix metalloproteinase-8 levels in periodontal disease patients: A systematic review. J Periodontal Res. 2018 Apr;53(2):156-163. Epub 2017 Sep 12. https://pubmed.ncbi.nlm.nih.gov/28898418/ https://onlinelibrary.wiley.com/doi/10.1111/jre.12495
  3. Arias-Bujanda N, Regueira-Iglesias A, Balsa-Castro C, Nibali L, Donos N, Tomás I. Accuracy of single molecular biomarkers in saliva for the diagnosis of periodontitis: A systematic review and meta-analysis. J Clin Periodontol. 2020 Jan;47(1):2-18. Epub 2019 Nov 20. https://pubmed.ncbi.nlm.nih.gov/31560804/ https://onlinelibrary.wiley.com/doi/10.1111/jcpe.13202
  4. Leone P, Tomas IC, Gupta S Ralsahen I, Sorsa T. The relationship between aMMP-8 and periodontitis—Systematic Review. Diagnostics 2023.

MMP-8 Science

  1. Uitto VJ, Suomalainen K, Sorsa T. Salivary collagenase. Origin, characteristics and relationship to periodontal health. J Periodont Res 1990;25:135-142. https://pubmed.ncbi.nlm.nih.gov/2163444/
  2. Sorsa T Tjäderhane L, Konttinen YT, Lauhio A, Salo T, Lee H-M, Golub LM, Brown DL, Mäntylä P. Matrix metalloproteinases: contribution to pathogenesis, diagnosis and treatment of periodontal inflammation. Ann Med 2006;38(5):306-21. https://pubmed.ncbi.nlm.nih.gov/16938801/
  3. Atanasova T, Stankova T, Bivolarska A, Vlaykova T. Matrix metalloproteinases in oral health—special attention on MMP-8. BiomedicinesMay 2023;11,(6):1514. https://pubmed.ncbi.nlm.nih.gov/37371608/
  4. Sorsa T, Mäntylä P, Tervahartiala T, Pussinen PJ, Gamonal J, Hernandez M. MMP activation in diagnostics of periodontitis and systemic inflammation. J Clin Periodontol. 2011 Sep;38(9):817-9. Epub 2011 Jun 26. PMID: 21707693. https://pubmed.ncbi.nlm.nih.gov/21707693/

Active MMP-8 and Oral Fitness

  1. Sorsa T, Mäntylä P, Rönkä H, Kallio P, Kallis GB, Lundqvist C, Kinane DF, Salo T, Golub LM, Teronen O, Tikanoja S. Scientific basis of a matrix metalloproteinase-8 specific chair-side test for monitoring periodontal and peri-implant health and disease. Ann N Y Acad Sci 1999 Jun 30;878:130-40. https://pubmed.ncbi.nlm.nih.gov/10415725/
  2. Mäntylä P, Stenman M, Kinane D, Salo T, Suomalainen K, Tikanoja S, Sorsa T. Monitoring periodontal disease status in smokers and nonsmokers using a gingival crevicular fluid matrix metalloproteinase-8-specific chair-side test. J Periodontal Res. 2006 Dec;41(6)503-12. https://pubmed.ncbi.nlm.nih.gov/17076774/
  3. Sorsa T, Tervahartiala T, Leppilahti J, Hernandez M, Gamonal J, Tuomainen AM, Lauhio A, Pussinen PJ, Mäntylä P. Collagenase-2 (MMP-8) as a point-of-care biomarker in periodontitis and cardiovascular diseases. Therapeutic response to non-antimicrobial properties of tetracyclines. Pharmacol Res. 2011 Feb;63(2):108–13. Epub 2010 Oct 16. https://pubmed.ncbi.nlm.nih.gov/20937384/
  4. Hernández M, Baeza M, Räisänen IT, Contreras J, Tervahartiala T, Chaparro A, Sorsa T, Hernández-Ríos P. Active MMP-8 quantitative test as an adjunctive tool for early diagnosis of periodontitis. Diagnostics (Basel). 2021 Aug 20;11(8):1503. https://pubmed.ncbi.nlm.nih.gov/34441437/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394100/ (Free PMC Article)†
  5. Aleksandrowicz P, Żelechowska P, Agier J, Starska K, Kędzierski K, Wysokińska-Miszczuk J, Brzezińska-Błaszczyk E. Evaluation of metalloproteinase-8 levels in crevicular fluid of patients with healthy implants or periodontitis. Mediators Inflamm. 2017;2017:4920847. Epub 2017 Jul 5. https://pubmed.ncbi.nlm.nih.gov/28757684/
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516710/ (Free PMC Article)
  6. Alassiri S, Parnanen P, Rathnayake N, Johannsen G, Heikkinen AM, Lazzara R, van der Schoor P, van der Schoor JG, Tervahartiala T, Gieselmann D, Sorsa T. The ability of quantitative, specific, and sensitive point-of-care/chair-side oral fluid immunotests for aMMP-8 to detect periodontal and peri-implant diseases. Dis Markers. 2018 Aug 5;2018:1306396.https://pubmed.ncbi.nlm.nih.gov/30154936/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098860/ ( Free PMC Article)
  7. Leppilahti JM, Sorsa T, Kallio MA, Tervahartiala T, Emingil G, Han B, Mäntylä P. The utility of gingival crevicular fluid matrix metalloproteinase-8 response patterns in prediction of site-level clinical treatment outcome. J Periodontol. 2015 Jun;86(6):777-87. Epub 2015 Mar 5. https://pubmed.ncbi.nlm.nih.gov/25741578/
  8. Lähteenmäki H, Kehinde A. Umeizudike. aMMP-8 point-of-care/chairside oral fluid technology as a rapid, non-invasive tool for periodontitis and peri-implantitis screening in a medical care setting. Diagnostics (Basel). 2020 Aug 5;10(8):562. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460514/ (Free PMC Article)
  9. Gul SS, Douglas CWI, Griffiths GS, Rawlinson A. A pilot study of active enzyme levels in gingival crevicular fluid of patients with chronic periodontal disease. J Clin Periodontol. 2016 Aug;43(8):629-36. Epub 2016 May 12. https://pubmed.ncbi.nlm.nih.gov/27106161/ https://onlinelibrary.wiley.com/doi/10.1111/jcpe.12568
  10. Alassiri S, Parnanen P, Rathnayake N, Johannsen G, Heikkinen A-M, Lazzara R, van der Schoor P, van der Schoor JG, Tervahartiala T, Gieselmann D, Sorsa T. The ability of quantitative, specific, and sensitive point-of-care/chair-side oral fluid immunotests for aMMP-8 to detect periodontal and peri-implant diseases. Dis Markers. 2018 Aug 5;2018:1306396. eCollection 2018 https://pubmed.ncbi.nlm.nih.gov/30154936/
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098860/ (Free PMC Article)
  11. Leppilahti JM, Herna ́ndez-Rı ́os PA, Gamonal JA, Tervahartiala T, Brignardello- Petersen R, Mantyla P, Sorsa T, Herna ́ndez M. Matrix metalloproteinases and myeloperoxidase in gingival crevicular fluid provide site-specific diagnostic value for chronic periodontitis. J Clin Periodontol 2014; 41: 348–356. Epub 2014 Feb https://pubmed.ncbi.nlm.nih.gov/24382144/
  12. Räisänen IT, Sorsa T, Tervahartiala T, Raivisto T, Heikkinen AM. Low association between bleeding on probing propensity and the salivary aMMP-8 levels in adolescents with gingivitis and stage I periodontitis. J Periodontal Res. 2021 Apr;56(2):289-297. Epub 2020 Dec 11. https://pubmed.ncbi.nlm.nih.gov/33305834/
  13. Grigoriadis A, Räisänen IT, Pärnänen P, Tervahartiala T, Sorsa T, Sakellari D. Prediabetes/diabetes screening strategy at the periodontal clinic. Clin Exp Dent Res. 2021 Feb;7(1):85–92. Epub 2020 Dec 10. https://pubmed.ncbi.nlm.nih.gov/33300692/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7853879/ (Free PMC Article)
  14. Loos BG, Van Dyke TE. The role of inflammation and genetics in periodontal disease. Periodontol 2000. 2020 Jun;83(1):26-39. https://pubmed.ncbi.nlm.nih.gov/32385877/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319430/ (Free PMC Article)
  15. Xanthopoulov V, Raiisanan I, Sorsa T, Sakellari D. Active MMP-8 as a biomarker of peri-implant health or disease. Eur J Dent. 2022 Sept 5. Epub ahead of print. PMID: 36063841. https://pubmed.ncbi.nlm.nih.gov/36063841/ https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0042-1753454
  16. Anders Hedenbjörk-Lager, Lars Bjørndal, Anders Gustafsson, Timo Sorsa, Leo Tjäderhane, Sigvard Åkerman, Dan Ericson; Caries Correlates Strongly with Salivary Levels of Matrix Metalloproteinase-8. Caries Res1 February 2015; 49 (1): 1 – 8. https://doi.org/10.1159/000360625

Treatment Related to Oral Fitness

  1. Sorsa T, Alassiri S, Grigoriadis A, Räisänen IT, Pärnänen P, Nwhator SO, Gieselmann DR, Sakellari D. Active MMP-8 (aMMP-8) as a grading and staging biomarker in the periodontitis classification diagnostics (Basel). 2020 Jan 22;10(2):61. https://pubmed.ncbi.nlm.nih.gov/31979091/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168924/ (Free PMC Article)
  2. Pfützner A, Schaedlich M, et al. The oral-systemic link: A review about the strong correlation between diabetes mellitus, periodontitis, and COVID-19. Outcome, Medical Research Archives [online] 2002;11(1).
  3. Keskin M, Rintamarttunen J, Gülçiçek E, Räisänen IT, Gupta S, Tervahartiala T, Pätilä T, Sorsa T. A comparative analysis of treatment-related changes in the diagnostic biomarker active metalloproteinase-8 levels in patients with periodontitis. Diagnostics (Basel). 2023 Feb 27;13(5):903. https://pubmed.ncbi.nlm.nih.gov/36900047/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10001139/ (Free PMC Article)
  4. Sorsa T, Alassiri S, Grigoriadis A, Räisänen IT, Pärnänen P, Nwhator SO, Gieselmann DR, Sakellari D. Active MMP-8 (aMMP-8) as a Grading and Staging Biomarker in the Periodontitis Classification. Diagnostics (Basel). 2020 Jan 22;10(2):61. doi: 10.3390/diagnostics10020061. PMID: 31979091; PMCID: PMC7168924.
  5. Räisänen, I.T.; Sorsa, T.; van der Schoor, G.-J.; Tervahartiala, T.; van der Schoor, P.; Gieselmann, D.-R.; Heikkinen, A.M. Active Matrix Metalloproteinase-8 Point-of-Care (PoC)/Chairside Mouthrinse Test vs. Bleeding on Probing in Diagnosing Subclinical Periodontitis in Adolescents. Diagnostics2019, 9,34.
     https://doi.org/10.3390/diagnostics9010034

Oral-Systemic Disease Link to Periodontal Disease

DIABETES
Grigoriadis A, Sorsa T, Räisänen I, Pärnänen P, Tervahartiala T, Sakellari D. Prediabetes/diabetes can be screened at the dental office by a low-cost and fast chair-side/point-of-care aMMP-8 immunotest. Diagnostics (Basel). 2019 Oct 17;9(4):151. https://pubmed.ncbi.nlm.nih.gov/31627410/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963402/ (Free PMC Article)

CARDIOVASCULAR DISEASE
Noack B, Kipping T, Tervahartiala T, Sorsa T, Hoffmann T, Lorenz K. Association between serum and oral matrix metalloproteinase-8 levels and periodontal health status. J Periodontal Res. 2017 Oct;52(5):824–831. Epub 2017 Mar 27.https://pubmed.ncbi.nlm.nih.gov/28345244/

ARTHRITIS
Kirchner A, Jäger J, Krohn-Grimberghe B, Patschan S, Kottmann T, Schmalz G, Mausberg RF, Haak R, Ziebolz D. Active matrix metalloproteinase-8 and periodontal bacteria depending on periodontal status in patients with rheumatoid arthritis. J Periodontal Res. 2017 Aug;52(4):745–754. Epub 2017 Mar 21. https://pubmed.ncbi.nlm.nih.gov/28321852/

ALZHEIMER’S DISEASE
Beydoun MA, Beydoun HA, Hossain S, El-Hajj ZW, Weiss J, Zonderman AB. Clinical and Bacterial Markers of Periodontitis and Their Association with Incident All-Cause and Alzheimer’s Disease Dementia in a Large National Survey. J Alzheimers Dis. 2020;75(1):157-172. https://pubmed.ncbi.nlm.nih.gov/32280099/

CANCER
Umeizudike K, Räisänen I, Gupta S, Nwhator S, Grigoriadis A, Sakellari D, Sorsa T. Active matrix metalloproteinase-8: A potential biomarker of oral-systemic link. Clin Exp Dent Res. 2022 Feb;8(1):359–365. Epub 2021 Nov 19. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874056/

HYPERTENSION
Del Pinto R, Landi L, Grassi G, Sforza NM, Cairo F, Citterio F, Paolantoni G, D’Aiuto F, Ferri C, Monaco A, Pietropaoli D; Italian working group on Hypertension, Periodontitis (Hy-Per Group). Hypertension and Periodontitis: A Joint Report by the Italian Society of Hypertension (SIIA) and the Italian Society of Periodontology and Implantology (SIdP). High Blood Press Cardiovasc Prev. 2021 Sep;28(5):427-438. Epub 2021 Sep 25. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484186/

PREGNANCY
Leppilahti JM, Harjunmaa U, Järnstedt J, Mangani C, Hernández M, Tervahartiala T, Lopez R, Ashorn U, Ashorn P, Gieselmann DR, Sorsa T. Diagnosis of Newly Delivered Mothers for Periodontitis with a Novel Oral-Rinse aMMP-8 Point-of-Care Test in a Rural Malawian Population. Diagnostics (Basel). 2018 Sep 15;8(3):67. doi: 10.3390/diagnostics8030067. PMID: 30223547; PMCID: PMC6164346. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164346/ (Free PMC Article)

Additional References Available Upon Request
†Disclaimer from The National Library of Medicine. As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, the contents by NLM or the National Institutes of Health.

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